دراسة نانو فيزياء جزيئ وحيد من الاحماض النووية (single DNA molecule) بواسطة اللاقطات الضوئية (Optical tweezers).

يمكننا باستخدام اللاقطات الضوئية عزل وإجراء قياسات نانوميكانيكية بدقة عالية لمتكون جزيئ أحماض نووية وحيد مع مركبات معدنية (DNA-ligand assembly) لأجل تحديد خصائصه الفيزيائية بالإضافة إلى استخلاص مسارالطاقة المحدد لتشكله الجزيئي

من الاهتمامات البحثية الأخرى: مواد النانو الكربونية مثل نانو أنابيب الكربون والغرافين.

فيما يلي الأوراق البحثية المحكمة المنشورة:

Almaqwashi, A.A., Kevek, J. W., Burton, R. M., DeBorde, T., & Minot, E. D. (2011). Variable-force microscopy for advanced characterization of horizontally aligned carbon nanotubes. Nanotechnology, 22(27), 275717

Almaqwashi, A.A., Paramanathan, T., Lincoln, P., Rouzina, I., Westerlund, F., & Williams, M. C. (2014). Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex. Nucleic acids research, 42, 11634-11641

Bahira, M., McCauley, M.J., Almaqwashi, A.A., Lincoln, P., Westerlund, F., Rouzina, I. and Williams, M.C. (2015) A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps. Nucleic acids research, 43, 8856-8867

Almaqwashi, A. A., Andersson, J., Lincoln, P., Rouzina, I., Westerlund, F., & Williams, M. C. (2016). Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation. Biophysical Journal, 110, 1255-1263

Almaqwashi, A. A., Paramanathan, T., Rouzina, I., & Williams, M. C. (2016). Mechanisms of small molecule–DNA interactions probed by single-molecule force spectroscopy. Nucleic Acids Research, 44, 3971-3988

Almaqwashi, A. A., Andersson, J., Lincoln, P., Rouzina, I., Westerlund, F., & Williams, M. C. (2016). DNA intercalation optimized by two-step molecular lock mechanism. Scientific Reports, 6, 379

Almaqwashi, A.A., Zhou, W., Naufer, M.N., Riddell, I.A., Yilmaz, Ö.H., Lippard, S.J. and Williams, M.C. (2019). DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin. JACS, 141 (4), 1537-1545

Fouda, A. N., El Shazly, M. D., & Almaqwashi, A. A. (2021). Facile and scalable green synthesis of N-doped graphene/CNTs nanocomposites via ball milling. Ain Shams Engineering Journal, 12 (1), 1017-1024

المشاركات البحثية في المؤتمرات العلمية:

American Physical Society March Meeting 2010, Portland, Oregon, Horizontally-aligned carbon nanotube films with nanotube diameter controlled by growth

American Physical Society NW meeting, 2011, Corvallis, Oregon, Acoustic cavitation of individual UCA microbubbles confined in capillaries

Biophysical Society 58^th, 2014, San Francisco, California, Quantifying the molecular mechanism for highly stereo-selective DNA threading intercalation

Biophysical Society 59th, 2015, Baltimore, Maryland, Resolving the DNA binding mode of a rotationally flexible binuclear ruthenium complex

American Physical Society March Meeting, 2015, San Antonio, Taxes, Quantifying the molecular mechanism for highly stereo-selective DNA threading intercalation

American Physical Society March Meeting, 2017, New Orleans, Louisiana, Resolving DNA-ligand intercalation in the entropic stretching regime

International conference on Advances in Functional Materials, 2019, Los Angeles, California, Synthesis of nitrogen doped graphene/carbon nanotubes nanocomposite using urea and humic acid